Biography

Tenured Professor and Doctoral Supervisor at Tsinghua University, Chief Physician, and Dean of the School of Healthcare Management at Tsinghua University.

As a renowned clinical expert in neurology and a strategic scientist in healthcare management in China, he has long been dedicated to innovative research on diagnostic and treatment technologies for cerebrovascular diseases. He actively promotes the in-depth integration of medicine with artificial intelligence and information technology, and participates in the development of smart healthcare systems and the reform of modern hospital management.

As a pioneer and leader in the field of neurovascular intervention in China, he introduced the country’s first self-expanding stent technology for the treatment of supra-aortic artery stenosis and published the first case report on the implantation of a self-expanding carotid artery stent. In the field of cerebrovascular diseases, he innovatively proposed the concept of the "Endovascular Diagnosis and Treatment Stroke Unit," establishing a new model for integrated diagnosis and treatment that combines technologies such as angiography, thrombolysis, and stent implantation. He led the development of an intelligent stroke prevention and treatment network system and oversaw the creation of China’s first specialized AI large model for cerebrovascular diseases, pioneering the application of artificial intelligence technology in the full-process management of such conditions. These efforts have significantly improved the precision and efficiency of diagnosis and treatment, with related achievements receiving multiple national invention patents.

Leveraging his profound clinical experience and cutting-edge technological insights, he has expanded his research into modern hospital management and healthcare system reform. He has successfully translated clinical expertise into management innovations, leading the standardization of hospital management and promoting the demonstration and application of "digital-intelligent healthcare" in major public health initiatives such as stroke prevention and treatment.

As the principal scientist, he has led multiple national key research initiatives, including projects under the National Key R&D Program and the National Natural Science Foundation of China. He has published over 200 academic papers in SCI and core journals and edited several academic works. Under his leadership, his team has established an intelligent prevention and treatment network for cerebrovascular diseases covering a population of over 10 million, achieving a systematic transition from individualized precision diagnosis and treatment to regionalized and intelligent health management. This demonstrates his value as a strategic scientist who bridges clinical medicine, technological innovation, and scientific management to continuously drive transformative improvements in the healthcare system.

Main Positions

Dean, School of Healthcare Management, Tsinghua University

Faculty Member, Tsinghua University/IDG-McGovern Institute for Brain Research

Director, Neurology Center, Beijing Tsinghua Changgung Hospital

Research Areas

1.Application of Digital Health and Medical Artificial Intelligence in Neurological Diseases

2.Research on Digital-Intelligent Healthcare Regulation and Ecosystem

3.Modern and Smart Hospital Management and Standardization

4.Full-Cycle and Population-Wide Smart Prevention and Treatment Systems for Chronic Diseases (including Stroke)

5.Novel Diagnostic and Therapeutic Technologies for Cerebrovascular Diseases (Stem Cells, Biomaterials, and Image Recognition)

6.Etiology and Drug Development for Cerebrovascular Diseases

Selected Academic Publications

2025

1.Song X, *Wu J et al. Stroke diagnosis and prediction tool using ChatGLM: development and validation study. J. Med. Internet Res. 27, e67010 (2025)

2.Xu W, *Wu J et al. Drug-coated balloon angioplasty for In-stent restenosis in the vertebral artery ostium: experiences from a single center. Vasc. Endovascular Surg. 59, 266–270 (2025)

3. Sang ZH, Xue SY, Wei CM, Wu J, et al. Research advances in motor function rehabilitation after cerebrovascular disease based on brain-computer interface technology. Chinese Journal of Stroke. 2025;20(1):63-69.

4. Xie ZQ, Wu J. Application of high-resolution magnetic resonance imaging in diagnosing intracranial atherosclerotic plaques and exploring stroke mechanisms. Journal of Apoplexy and Nervous Diseases. 2025;42(2):187-192.

5. Song XW, Yin W, Li JQ, Wu J, et al. Identification and diagnosis of large vessel occlusion in acute ischemic stroke using ChatGLM. Chinese Journal of Stroke. 2025;20(1):70-77.

6. Song XW, Jia XB, Wu J. Application and prospects of artificial intelligence technology in acute stroke imaging diagnosis. Chinese Journal of Cerebrovascular Diseases. 2025;22(2):75-80.

7. Wu YT, Wei CM, Sang ZH, Wu J, et al. Advances in the application of wearable devices for stroke risk prediction and post-stroke management. Chinese Journal of Stroke. 2025;20(1):55-62.

8. Pi JT, Yin W, Song XW, Wu J, et al. Investigation on the cognition, attitude, and functional needs of neurologists with different seniority levels toward digital-intelligent diagnosis and treatment. Chinese Journal of Stroke. 2025;20(1):78-86. DOI:10.3969/j.issn.1673-5765.2025.01.010.

9. Li XM, Song XF, Wu J, et al. Practicing digital-intelligent health management to improve the quality and efficiency of stroke patient management in China. Chinese Journal of Stroke. 2025;20(1):29-39. DOI:10.3969/j.issn.1673-5765.2025.01.004.

2024

1.Xue S, *Wu J et al. Unveiling frequency-specific microstate correlates of anxiety and depression symptoms. Brain Topogr. 38, 12 (2024).

2.Li M, *Wu J et al. The relationship between intracranial atherosclerosis and white matter hyperintensity in ischemic stroke patients: a retrospective cross-sectional study using high-resolution magnetic resonance vessel wall imaging. Quant. Imaging Med. Surg. 14, 6002–6014 (2024).

3.Jiang Y, *Wu J et al. Morning blood pressure surge and intracranial atherosclerotic plaque characteristics: a high-resolution magnetic resonance vessel wall imaging study. Br. J. Radiol. 97, 210–220 (2024).

4.Zhang J., Wei, C. & Wu, J. Ischemic stroke with positive antiphospholipid antibodies in bloom syndrome: a case report. J. Stroke Cerebrovasc. Dis.: Off. J. Natl. Stroke Assoc. 33, 107490 (2024).

5.Song X, *Wu J et al. Imaging biomarker associated with early neurological deterioration in isolated pontine infarction. Front. Neurol. 15, 1492166 (2024).

6.Song X, *Wu J et al. Decreased flow in ischemic stroke with coexisting intracranial artery stenosis and white matter hyperintensities. J. Cent. Nerv. Syst. Dis. 16, 11795735241266572 (2024).

7.Li S, *Wu J et al. Clinical and prognostic characteristics of acute BAD-related stroke: a multicenter MRI-based prospective study. Stroke 55, 2431–2438 (2024).

8. ZHANG J, WU J. Current status of Pseudomonas aeruginosa infections in acute cerebrovascular diseases and research progress in related vaccines. Journal of Pathogen Biology. 2024;19(7):867-868, Back Cover. DOI:10.13350/j.cjpb.240726.

9. WANG Y, WEI CM, LI XL, WU J, et al. Application of diversified teaching models in stroke green channel training at university-affiliated teaching hospitals. Chinese Journal of Stroke. 2024;19(9):1102-1109.

10. HU SM, LI F, GUAN SC, WU J, et al. Prevalence and 5-year mortality of dementia among elderly individuals in Beijing and its relationship with geriatric syndromes. Chinese Journal of Epidemiology. 2024;45(11):1573-1581.

2023

1. Chen W, Song X, Chen S, Chen Z, Fu M, Wei C, Zheng Z, *Wu J, *Li R.Variations of Arterial Compliance and Vascular Resistance due to Plaque or infarct in a Single Vascular Territory of Middle Cerebral Artery[J]. Quantitative Imaging in Medicine and Surgery.2023

2. SONG XW, SANG ZH, HOU DD, WU J, et al. Correlation between circadian blood pressure rhythm and characteristics of intracranial atherosclerotic plaques. Chinese Journal of Stroke. 2023;18(1):60-67.

3. GUO YD, WU J, SONG XW. Role of DWI combined with BNP, CysC, and LDH detection in prognostic evaluation of acute cerebral infarction. Journal of Molecular Diagnostics and Therapy. 2023;15(7):1164-1168.

4. SHEN Y, WU J. Selection of antihypertensive drugs for secondary prevention of ischemic stroke. Chinese Journal of Stroke. 2023;18(1):54-59.

5. WU YT, WEI CM, WU J. Research progress on the relationship between blood pressure levels and post-stroke cognitive impairment. Chinese Journal of Stroke. 2023;18(1):68-75.

6. SONG XW, HOU DD, ZHAO L, WU J, et al. Current status of discharge summaries in stroke patients and its correlation with standardized residency training. Chinese Journal of Stroke. 2023;18(5):610-615.

7. ZHANG DD, ZHANG JX, SU N, WU J, et al. A national multicenter clinical study on establishing digital cognitive norms for cognitively normal adults in China. Chinese Journal of Cerebrovascular Diseases (Electronic Edition). 2023;17(3):179-199.

2022

1.SONG XW, ZHAO HL, CHEN WW, WU J, et al. Application of 4D flow MRI in hemodynamic assessment of stroke patients with intracranial arterial stenosis. Chinese Journal of Neurology. 2022;55(1):53-59.

2.ZHANG XF, XU WD, WU J. Impact of left atrial enlargement on prognosis in acute ischemic stroke. National Medical Journal of China. 2022;102(9):4.

3.Zhao Y, Liu B, Wang C, Fang X, *Wu J,et al. Prevalence and Risk Factors Comparison of Anterior and Posterior Intracranial Arterial Stenosis[J]. Evidence-Based Complementary and Alternative Medicine, 2022,

4.Chen W, Song X, Chen S, *Wu J，et al. Blood flow and perfusion lateralization in border zone infarct using 4D flow and arterial spin labeling[J]. Neuroradiology, 2022: 1-8.

5.Zhao X, Feng X, Li X, *Wu J，et al. The G41D mutation in SOD1-related amyotrophic lateral sclerosis exhibits phenotypic heterogeneity among individuals: A case report and literature review[J]. Medicine, 2022, 101(6).

6. SONG XW, WU J. Research advances and current therapeutic landscape of stroke associated with non-stenosing high-risk atherosclerotic plaques. National Medical Journal of China. 2022;102(31):2470-2473.

2021

1. FENG XH, WU J. Research advances in neuralgic amyotrophy. Chinese Journal of Hand Surgery. 2021;37(4):4

2.Gao C, Jia W, Xu D，*Wu J et al. Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke[J]. Journal of neuroinflammation, 2021, 18(1): 1-16.

3.Song, X., Wei, Q., Zhao, X., Hou, D., Zhao, H., Wang, L., ... & *Wu J. (2021). Association between Short-Term Blood Pressure Variability and Intracranial Atherosclerotic Plaque Vulnerability: A High-Resolution Magnetic Resonance Imaging Study. Journal of atherosclerosis and thrombosis, 63164.

4.Jia, W., Wang, Z., Gao, C., *Wu,J, & Wu, Q. (2021). Trajectory modeling of endothelial-to-mesenchymal transition reveals galectin-3 as a mediator in pulmonary fibrosis. Cell death & disease, 12(4), 1-14.

5. ZHANG XF, XU WD, WU J. Correlation between white matter lesions and blood pressure variability in patients with acute ischemic stroke. Chinese Journal of Cerebrovascular Diseases (Electronic Edition). 2021;15(3):153-156.

6. WANG Y, FU W, WU J. Rescue stenting for failed mechanical thrombectomy in basilar artery occlusion: A case report and literature review. Chinese Journal of Cerebrovascular Diseases (Electronic Edition). 2021;15(5):

7. WEI CM, SANG ZH, WU J. Current status and advances in blood pressure management for acute ischemic stroke. Chinese Journal of Cerebrovascular Diseases (Electronic Edition).

8. SONG XW, ZHAO HL, CHEN WW, LI R, HOU DD, ZHENG ZZ, WU J. Application of 4D flow MRI in hemodynamic assessment of stroke patients with intracranial arterial stenosis. Chinese Journal of Neurology. 2022;55(1):53-59.

9. SONG XW, HOU DD, WU J. Advances in imaging biomarkers for recurrent stroke in intracranial atherosclerotic disease. Chinese Journal of Cerebrovascular Diseases (Electronic Edition). 2021;15(3):130-134.

2020

1.Song X，*Wu J，et al.  Association between blood pressure and intracranial artery stenosis in a Chinese population[J]. The Journal of Clinical Hypertension, 2020

2. SONG XW, WU J. Impact of anatomical variations in the Circle of Willis on hemodynamic distribution in intracranial arterial stenosis: research advances. National Medical Journal of China. 2020;100(1):3.

3. WU J, SONG XW, WEI CM, et al. Technological innovations driving the evolution of stroke diagnosis and treatment paradigms. Chinese Journal of Cerebrovascular Diseases (Electronic Edition). 2020;14(1):4.

4.Yang L , Wu J , Zhang J . A Novel CCM2 Gene Mutation Associated With Cerebral Cavernous Malformation[J]. Frontiers in Neurology, 2020, 11.

5.Song X , Zhao X , Liebeskind D S , *Wu J et al. Associations between systemic blood pressure parameters and intraplaque hemorrhage in symptomatic intracranial atherosclerosis: a high-resolution MRI-based study[J]. Hypertension Research, 2020, 43(7)

6.Li J , Zhao L , Wang Z , *Wu J et al. Association of Serum Indirect Bilirubin Concentrations with Motor Subtypes of Parkinson's Disease[J]. Neurodegenerative Diseases, 2020, 19(3-4):1-7.

7.Xu W , Gao C , *Wu J CD151 Alleviates Early Blood–Brain Barrier Dysfunction After Experimental Focal Brain Ischemia in Rats[J]. Cellular and Molecular Neurobiology, 2020:1-12.

8.Song X , Zhao X , Liebeskind D S , *Wu J et al. Incremental value of plaque enhancement in predicting stroke recurrence in symptomatic intracranial atherosclerosis[J]. Neuroradiology, 2020.

9. FENG XH, WU J. Advances in electrophysiological diagnosis of Lambert-Eaton myasthenic syndrome. National Medical Journal of China. 2020;100(17):3.

10. SONG XW, WU J. Impact of acute-phase blood pressure fluctuations on cerebral blood flow metabolism in ischemic stroke: research progress. Chinese Journal of Cerebrovascular Diseases. 2020;17(8):5.

11. SONG XW, WEI CM, XU WD, WU J, et al. Incidence and associated factors of intraplaque hemorrhage in stroke patients with intracranial atherosclerosis. National Medical Journal of China. 2020;100(33):6.

12. LI J, ZHAO L, FU W, WU J, et al. Clinical study on the influence of inflammation on severe stenosis or occlusion of intracranial and extracranial arteries. Chinese Journal of Contemporary Neurology and Neurosurgery. 2020;(9):6.

13. FENG XH, WU J. Clinical identification of non-traumatic brachial plexus injuries. National Medical Journal of China. 2020;100(45):3.

Other Representative Publications

1. Wu J., Nataliya I. Lenchik, et al. Gerling. Microarray Data Analysis and Mining Strategy to Reduce Type 1 and Type 2 Errors. BMC-Genomics. 2008. Sep. 16;9:S12.

2. Wu J, Marler J, et al. Strain differences in allele and expression levels of CD72 on B-lymphocytes from NOD, AKR, NON and C57Bl/6 mice. Immunol. Lett. 2006 Mar 15; 103(2):115-20.

3. Gerling IC, Singh S, Lenchik NI, Marshall DR, Wu J. New Data-Analysis and Mining Approaches Identify Unique Proteome and Transcriptome Markers of Susceptibility to Autoimmune Diabetes. Mol Cell Proteomics. 2006 Feb; 5(2):293-305.

4. Chantal M. Longo-Guess, Leona H. Gagnon, Susan A. Cook, Jian Wu, et al. A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice. PNAS. 2005 May 31; 102(22):7894-9.

5.Solomon S. Solomon, Nick Buss, James Shull, Susie Monnier, Gipsy Majumdar, Jian Wu, et al. Proteome of H-411E (liver) cells exposed to insulin and tumor necrosis factor-alpha: Analysis of proteins involved in insulin resistance. J Lab Clin Med. 2005 May; 145(5):275-83.

6.Jian Wu, Nataliya I Lenchik, et al. Functional characterization of two-dimensional gel-separated proteins using sequential staining. Electrophoresis. 2005 Jan;26(1):225-37.

7.Nilish S. Tannu*, Jian Wu*, et al. The paraffin wax coated plates as matrix-assisted laser desorption/ionization (MALDI) sample support for high throughput identification of proteins by peptide-mass fingerprinting. Analytical Biochemistry. 2004. 327: 222~232 (* co-first author).

8.WU J, WANG YJ, LI SM, LI KC, YAN ZY, WANG P, HUA Y. (2000). Comparative study of ultrasound, MRA, and DSA in 37 patients with carotid atherosclerosis. Chinese Journal of Geriatric Heart Brain and Vessel Diseases. 2000;2(1):35-38.

9.WU J, WANG YJ. (1999). Percutaneous carotid angioplasty. Foreign Medical Sciences (Cerebrovascular Diseases Section). 1999;7(1):42-44.

10.WU J, WANG YJ, LI SM, DONG ZJ, YAN ZY, HUA Y, WANG P. (1999). Endovascular stenting for severe carotid atherosclerotic stenosis: A report of three cases. Chinese Journal of Neurology. 1999;32(3):168-170.

11.WU J. (1997). Evaluation of carotid atherosclerosis. Foreign Medical Sciences (Neurology and Neurosurgery Section). 1997;(2):62-65.

12. WU J, WU Y. (1994). Cerebrolysin treatment for olivopontocerebellar atrophy. Chinese Journal of New Drugs and Clinical Medicine. 1994;(6):369-370.